After Keita Suminoe's mother passed away, his father promptly remarried, introducing two step-sisters into Keita's life: twins Ako and Riko. But since their fateful first encounter, a surge of incestuous love for their younger brother overcame the girls, beginning a lifelong feud for his heart. Now at the end of his middle school career, Keita studies fervently to be able to attend Ako and Riko's high school. While doing so however, he must resolve his conflicting feelings for his siblings and either reject or succumb to his sisters' intimate advances. Fortunately—or perhaps unfortunately for Keita—his sisters aren't the only women lusting after him, and there's no telling when the allure of temptation will get the better of the boy as well.

Haruka and Sora Kasugano are coming home, to a place filled with memories. Having lost their parents in a tragic car accident, the twins resolve to return to the countryside and start life anew at their grandfather's house, the haunt a constant reminder of moments from their past. Greeting them are childhood friends Nao Yorihime and Akira Amatsume, and newcomer Kazuha Migiwa. It is a warm welcome, symbolic of the days that should come. Their peace is merely ephemeral, however, as suppressed emotions, born from vows both newfound and forgotten, start exerting their influence on the twins' new lives. And deep down, a dark secret, only known to them, begins to unshackle. Based on the visual novel by Sphere, Yosuga no Sora not only explores the power of lost memories and true love when the bonds of many become intertwined, but also raises the questions of morality and social acceptance.

Being the first female student council president isn't easy, especially when your school just transitioned from an all boys high school to a co-ed one. Aptly nicknamed "Demon President" by the boys for her strict disciplinary style, Misaki Ayuzawa is not afraid to use her mastery of Aikido techniques to cast judgment onto the hordes of misbehaving boys and defend the girls at Seika High School. Yet even the perfect Ayuzawa has an embarrassing secret—she works part-time as a maid at a maid café to help her struggling family pay the bills. She has managed to keep her job hidden from her fellow students and maintained her flawless image as a stellar student until one day, Takumi Usui, the most popular boy in school, walks into the maid café. He could destroy her reputation with her secret... or he could twist the student council president around his little finger and use her secret as an opportunity to get closer to her.

As with both the Advanced Generation and Diamond & Pearl series before it, the Best Wishes! series begins with only Satoshi, headed off to the Isshu region, located far away from Kanto, Johto, Houen, and Sinnoh, with his Pikachu. After he meets up with the new trainer and rival Shooty and the region's Professor Araragi, he gains traveling companions in Iris, a girl from a town known for its Dragon Pokémon, and Dent, Pokémon Connoisseur and the Grass Pokémon specialist of the three Sanyou City Gym Leaders.